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Project 1: Effects of ageing on use of probabilistic task cueing in relation to initiation of hand movement and gait.

PI: J.Rothwell, University College London

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Project 3: The role of subcomponents of the basal ganglia in the control of locomotion and orienting response.

PI: Prof. Sten Grillner, Karolinska Institute

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Project 5: Virtual reality applications with real-time feedback for defining balance and gait parameters in PD.

PI: Dr. Frans Steenbrink, Motek Medical BV

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Project 7: Development of a conceptual model for PD.

PI: PD Dr. Walter Maetzler, Eberhard Karls University of Tuebingen

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Project 9: Understanding and quantifying gait and balance quality to improve therapy of gait disorders.

PI: Dr. Andreas Koll, Hocoma AG

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Example Frame

WP1: Improve understanding of supraspinal motor control


WP2: Improve ambulatory diagnostics of supraspinal movement control deficits


WP3: Improve treatment of supraspinal control motor deficits


The basal ganglia and cortical areas are important nodes of the supraspinal motor control system. Despite advances in the understanding of underlying circuits, large gaps remain. We focus on the improvement of the understanding of supraspinal movement control.

We aim to improve diagnostics of motor control at the border of healthy ageing and neurodegeneration as well as in PD, by use of instrumented clinical assessment tools in large cohorts, virtual reality approaches in conjunction with real-time EEG feedback and by long-term axial and distal movement monitoring.

Modern therapy and rehabilitation concepts for gait and balance disorders demand task- specific and individual training, and must consider supraspinal mechanisms that occur with ageing and in the course of neurodegenerative diseases that can impede successful movement. We aim to develop strategies targeting freezing of gait and, by using a model-based approach, quantifying gait and balance quality to improve individualized therapy of the ageing population with movement disorders in a rehabilitation setting.